| Expression pattern: |
DN |
| Associated gene: |
ABHD5, ATGL, p53, p65, p-p65 |
| Associated microRNA: |
- |
| Biological function: |
Circ_cMras acts as a tumor suppressor in LAC, inhibiting cell proliferation, migration, invasion and tumor growth, while promoting apoptosis. |
| Molecular mechanism: |
Circ_cMras positively regulates ABHD5 and ATGL, increases p53, inhibits NF-kappaB pathway activation, and suppresses LAC progression through the circ_cMras/ABHD5/ATGL/NF-kappaB axis. |
| Biological pathway or process: |
NF-kappaB (inhibits); p53 signaling (promotes); proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ_cMras might provide a novel insight for the diagnosis and prognosis of LAC. |
| Description: |
Circ_cMras is down-regulated in lung adenocarcinoma tissues and cells. Its overexpression suppresses proliferation, migration, invasion and xenograft tumor growth, promotes apoptosis, and acts through positive regulation of the ABHD5/ATGL axis with inhibition of NF-kappaB signaling and increased p53. |
| Confidence score: |
0.6278 |