circRNA basic information
circBase ID: hsa_circ_0001772
Name: hsa_circ_RBM33
Synonym: circRBM33
Host Gene: RBM33
Genomic location(hg19): chr7:155465560-155473602:+
Genomic location(hg38): chr7:155672866-155680908:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; paracancerous tissues
Cell lines:

MGC-803; BGC-823; SGC-7901; AGS; GES-1; HEK293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IL-6
Associated microRNA: miR-149
Biological function: circRBM33 promotes GC cell proliferation, migration and invasion, and inhibits apoptosis; silencing circRBM33 decreases proliferation, migration and invasion and increases apoptosis.
Molecular mechanism: circRBM33 acts as a sponge for miR-149 and modulates IL-6 levels through the circRBM33/miR-149/IL-6 axis.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

circRBM33 upregulation was associated with advanced TNM stage, position of the tumor, lymph node metastasis, poor differentiation, and large tumor size; circRBM33 may act as a tumor biomarker and potential therapeutic target.
Description:

hsa_circ_0001772/circRBM33 is upregulated in gastric cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, circRBM33 promotes GC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circRBM33 binds miR-149 and modulates IL-6 levels through the circRBM33/miR-149/IL-6 axis, suggesting potential biomarker and therapeutic relevance.
Confidence score:

0.6536
Other information
Title:

CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2020
PubMed ID: 32044717
Study type:

combined biological and clinical study
Data availability: Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.biopha.2020.109876.
Code availability: -