| Expression pattern: |
UP |
| Associated gene: |
COL1 mRNA, COL1 |
| Associated microRNA: |
miR-615-5p |
| Biological function: |
circZNF609 is involved in FSGS pathogenesis, positively correlates with podocyte injury and renal fibrosis, and may promote COL1 overproduction by sponging miR-615-5p. |
| Molecular mechanism: |
ceRNA mechanism: circZNF609 may sponge miR-615-5p, thereby increasing COL1 production and contributing to renal fibrosis and podocyte injury in FSGS. |
| Biological pathway or process: |
ceRNA regulation (promotes); fibrosis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circZNF609 expression increased in renal biopsies of FSGS patients and may be a novel therapeutic target for FSGS. |
| Description: |
circZNF609 is up-regulated in Adriamycin-induced FSGS mouse kidneys, BSA-exposed HK-2 cells, and renal biopsies from FSGS patients. The study suggests that circZNF609 contributes to FSGS pathogenesis through a circZNF609/miR-615-5p/COL1 ceRNA mechanism, promoting podocyte injury and renal fibrosis. |
| Confidence score: |
0.4997 |