| Expression pattern: |
UP |
| Associated gene: |
ZC3H13, AMPK/p53 pathway, AMPK, p53 |
| Associated microRNA: |
- |
| Biological function: |
Promotes malignant characteristics of cervical cancer cells, including cell growth, proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
ZC3H13-mediated m6A modification increases the stability of hsa_circ_0081723, and hsa_circ_0081723 promotes cervical cancer progression by blocking the AMPK/p53 signaling pathway. |
| Biological pathway or process: |
AMPK (inhibits); p53 signaling (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); m6A modification (other); mRNA stability (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; MeRIP / MeRIP-seq; Actinomycin D / DRB Stability Assay |
| Clinical significance: |
Higher hsa_circ_0081723 levels indicated high histological grade, high FIGO stage, poor differentiation, and poor prognosis in cervical cancer patients. |
| Description: |
hsa_circ_0081723 is up-regulated in cervical cancer tissues and its high expression is associated with advanced clinicopathological features and poor prognosis. Functionally, it promotes cervical cancer cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, ZC3H13-mediated m6A modification increases hsa_circ_0081723 stability, while hsa_circ_0081723 promotes cervical cancer progression by suppressing the AMPK/p53 pathway. |
| Confidence score: |
0.8353 |