| Expression pattern: |
UP |
| Associated gene: |
ADAM9, Ago2 |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
promotes oxaliplatin resistance, proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0000144 sponges miR-502-5p to positively regulate ADAM9 |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0000144 is up-regulated in oxaliplatin-resistant gastric cancer tissues/cells and promotes OXA resistance and malignant behaviors. Mechanistically, it functions as a ceRNA by sponging miR-502-5p to increase ADAM9, and its knockdown suppresses tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7897 |