| Expression pattern: |
UP |
| Associated gene: |
E2F3, eIF4A3 |
| Associated microRNA: |
miR-599 |
| Biological function: |
promotes proliferation, migration, invasion, glycolysis and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circWAC sponges miR-599 to up-regulate E2F3; circWAC expression is induced by eIF4A3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
circWAC has diagnostic value (ROC AUC=0.8996) and high circWAC is associated with short survival time and aggressive clinicopathological features (large tumor size, advanced TNM stage, positive lymph node metastasis). |
| Description: |
circWAC is up-regulated in breast cancer and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis and tumor growth while inhibiting apoptosis, mainly by sponging miR-599 to increase E2F3; eIF4A3 positively regulates circWAC biogenesis/expression. |
| Confidence score: |
0.8789 |