circRNA basic information
circBase ID: -
Name: hsa_circ_CUX1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 8533
DO name: hypopharynx cancer
Disease details: hypopharyngeal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SCC-4, SCC-9, SCC-15, CLA-27, SAS, Tca-8113
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circCUX1 binds to Caspase1 and inhibits its expression, resulting in a decrease in the release of inflammatory factors, thereby developing tolerance to radiotherapy. Our findings indicate that circCUX1 is a potential therapeutic target for radiotherapy tolerance in HPSCC patients.
Other information
Title:

N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway.

Journal: Cell Death Dis
Published: 2021/3/21
PubMed ID: 33741902