| Expression pattern: |
DN |
| Associated gene: |
TP53INP1 |
| Associated microRNA: |
miR-190a-3p |
| Biological function: |
promotes apoptosis and inhibits breast cancer cell viability, proliferation, migration, invasion, and malignant phenotype |
| Molecular mechanism: |
circCDYL acts as a miRNA sponge for miR-190a-3p, down-regulates miR-190a-3p, relieves miR-190a-3p-mediated inhibition of TP53INP1, and up-regulates TP53INP1 |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circCDYL expression is associated with longer survival; circCDYL is a potential therapeutic target and may be used for the diagnosis of breast cancer |
| Description: |
circCDYL is down-regulated in triple negative breast cancer tissues and cell lines, and higher expression is associated with longer patient survival. Functionally, circCDYL acts as a tumor suppressor by sponging miR-190a-3p, thereby up-regulating TP53INP1 and promoting apoptosis while inhibiting proliferation, migration, and invasion. |
| Confidence score: |
0.7113 |