| Expression pattern: |
UP |
| Associated gene: |
KIF18A, kinesin family member 18A, Ago2, Argonaute2 |
| Associated microRNA: |
miR-30b-5p |
| Biological function: |
circ_CCNB2 knockdown enhanced radiosensitivity of irradiation-resistant PCa cells, inhibited colony formation, migration, invasion, metastasis-related markers and autophagy, and promoted apoptosis; circ_CCNB2 overexpression was associated with radioresistance and autophagy promotion. |
| Molecular mechanism: |
circ_CCNB2 functions as a sponge for miR-30b-5p and positively regulates KIF18A expression through the miR-30b-5p/KIF18A axis, thereby promoting autophagy and radioresistance in prostate cancer. |
| Biological pathway or process: |
autophagy (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); radioresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Clinical Sample Validation; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
circ_CCNB2 has potential to predict radioresistance in PCa radiotherapy and its suppression may improve radiotherapy response in recurrent PCa patients. |
| Description: |
circ_CCNB2 is upregulated in prostate cancer, especially in irradiation-resistant PCa tissues and cells. It promotes radioresistance by sponging miR-30b-5p to increase KIF18A expression and enhance autophagy; knockdown of circ_CCNB2 sensitizes PCa cells and xenografts to radiation. |
| Confidence score: |
0.7045 |