circRNA basic information
circBase ID: hsa_circ_0000376
Name: -
Synonym: circ_0000376
Host Gene: -
Genomic location(hg19): chr12:11199618-11248400:-
Genomic location(hg38): chr12:11047019-11095801:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: Non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent normal bronchial tissues; NSCLC clinical samples
Cell lines:

A549; NCI-H460; 16HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: E-cadherin, N-cadherin, Vimentin
Associated microRNA: miR-384
Biological function: Circ_0000376 promotes NSCLC cell proliferation, migration, invasion, EMT, metastasis, and cisplatin chemoresistance.
Molecular mechanism: Circ_0000376 binds to and represses miR-384; circ_0000376 regulates NSCLC cell proliferation, migration, invasion, metastasis, and drug resistance by targeting miR-384.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; BrdU; IF (Immunofluorescence); Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

High circ_0000376 expression is linked to unfavorable pathological parameters, increased tumor T stage, and local lymph node infiltration, and may serve as a diagnostic biomarker and therapy target.
Description:

Circ_0000376 is up-regulated in NSCLC tissues and cell lines and is associated with unfavorable clinicopathological indicators. Functionally, it promotes proliferation, migration, invasion, EMT, metastasis, and cisplatin chemoresistance of NSCLC cells. Mechanistically, circ_0000376 binds to miR-384 and represses its expression, thereby contributing to malignant phenotypes in NSCLC.
Confidence score:

0.6536
Other information
Title:

Circ_0000376 enhances the proliferation, metastasis, and chemoresistance of NSCLC cells via repressing miR-384.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2020
PubMed ID: 32716343
Study type:

combined biological and clinical study
Data availability: -
Code availability: -