circRNA basic information
circBase ID: -
Name: hsa_circ_ARHGAP5
Synonym: circARHGAP5-1
Host Gene: ARHGAP5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011122
MONDO name: obesity disorder
Disease details: obesity
Disease DO ID:
 9970
Disease MeSH ID:
 -
Disease NCIt ID:
 C3283
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human fat; human white adipocytes; human subcutaneous adipose tissue
Cell lines:

immortalized human white fat progenitor cells
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Promotes human adipogenesis; knockdown suppresses adipogenic markers and lipid accumulation.
Molecular mechanism: Functional conservation of the ARHGAP5 circRNA homolog in human adipocytes; detailed molecular mechanism not specified.
Biological pathway or process:

lipid metabolism (promotes); other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Oil Red O Staining; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for obesity-related metabolic diseases.
Description:

circARHGAP5-1 is the human homologous circRNA from the ARHGAP5 locus. Although its obesity-specific expression change was not established, functional knockdown in immortalized human white fat progenitor cells suppressed adipogenesis and lipid accumulation, suggesting conservation of the pro-adipogenic ARHGAP5 circRNA function in humans.
Confidence score:

0.3684
Other information
Title:

Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis.

Journal: Nature metabolism
Published: 2019
PubMed ID: 32694641
Study type:

combined biological and bioinformatics study
Data availability: GSE118762
Code availability: -