| Expression pattern: |
UP |
| Associated gene: |
FOXP4, AGO2 |
| Associated microRNA: |
miR-491 |
| Biological function: |
promotes CRC cell proliferation/viability |
| Molecular mechanism: |
ceRNA sponge of miR-491 leading to modulation of FOXP4 expression; associated with AGO2-containing RISC |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In colorectal cancer, circ-0000212 is up-regulated and mainly localized in the cytoplasm. It promotes CRC cell proliferation by acting as a miR-491 sponge, thereby relieving miR-491-mediated repression of FOXP4 and increasing FOXP4 expression. |
| Confidence score: |
0.8191 |