| Expression pattern: |
UP |
| Associated gene: |
RAB27A |
| Associated microRNA: |
miR-31-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth in vivo; promotes bladder cancer progression and recurrence |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-31-5p, thereby enhancing RAB27A expression (ceRNA axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ-BPTF expression is associated with higher tumor grades, recurrence, and poorer prognosis (worse OS) in BCa patients. |
| Description: |
circ-BPTF (hsa_circ_0000799) is up-regulated in bladder cancer tissues/cell lines and is associated with recurrence and poor overall survival. It promotes BCa proliferation and motility and acts as a ceRNA by sponging miR-31-5p to increase RAB27A expression; knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.8814 |