circRNA basic information
circBase ID: hsa_circ_0088036
Name: hsa_circ_SUSD1
Synonym: -
Host Gene: SUSD1
Genomic location(hg19): chr9:114840817-114842445:-
Genomic location(hg38): chr9:112078537-112080165:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

synovial tissues
Cell lines:

RA-FLSs; OA-FLSs; 293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SIRT 1
Associated microRNA: miR-140-3p
Biological function: Upregulated circ0088036 promotes the proliferation and migration of RA-FLSs and contributes to RA progression.
Molecular mechanism: circ0088036 acts as a miR-140-3p sponge to upregulate SIRT 1 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other); inflammation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; EdU Staining; Transwell Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

circ0088036 may be a new therapeutic target for RA.
Description:

hsa_circ_0088036/circ0088036 is upregulated in RA fibroblast-like synoviocytes. It promotes RA-FLS proliferation and migration by sponging miR-140-3p and increasing SIRT 1 expression, suggesting a pro-inflammatory role and potential therapeutic relevance in RA.
Confidence score:

0.6479
Other information
Title:

Hsa_circ_0088036 promotes the proliferation and migration of fibroblast-like synoviocytes by sponging miR-140-3p and upregulating SIRT 1 expression in rheumatoid arthritis.

Journal: Molecular immunology
Published: 2020
PubMed ID: 32673817
Study type:

combined biological and clinical study
Data availability: -
Code availability: -