| Expression pattern: |
UP |
| Associated gene: |
PTPRE |
| Associated microRNA: |
miR-383-5p |
| Biological function: |
CircETV6 promotes HCC cell proliferation, migration, invasion, cell cycle progression, tumor growth and metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
CircETV6 acts as a miR-383-5p sponge to upregulate PTPRE expression, thereby promoting HCC malignant development. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; IHC (Immunohistochemistry); In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circETV6 expression is associated with lower 5-year overall survival rate, tumor size and TNM stage in HCC patients; it may provide a new molecular target for HCC treatment. |
| Description: |
CircETV6 is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. It promotes HCC proliferation, migration, invasion, cell cycle progression, tumor growth and metastasis while suppressing apoptosis, mainly through sponging miR-383-5p to increase PTPRE expression. High circETV6 expression is associated with poor overall survival and adverse clinicopathological features, suggesting potential therapeutic relevance. |
| Confidence score: |
0.8656 |