circRNA basic information
circBase ID: hsa_circ_0072309
Name: hsa_circ_IRAK3
Synonym: -
Host Gene: IRAK3
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005036
MONDO name: gastric adenocarcinoma
Disease details: poorly differentiated gastric adenocarcinoma
Disease DO ID:
 3717
Disease MeSH ID:
 -
Disease NCIt ID:
 C4004
Disease ICD11 ID:
 1855471719
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PDGA tissues; paired noncancerous tissues; GC tissues; adjacent tissues
Cell lines:

GES-1; MGC803; AGS; SGC7901
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic marker for GC and PDGA; down-regulated DEC with significant correlation between m6A level and circRNA expression.
Molecular mechanism: m6A modification level was significantly correlated with hsa circ 0072309 expression level.
Biological pathway or process:

m6A modification (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; MeRIP / MeRIP-seq; Bioinformatics Analysis
Clinical significance:

Potential diagnostic marker of GC and PDGA; AUC 0.858 for GC and 0.866 for PDGA.
Description:

hsa_circ_0072309 was down-regulated in PDGA/GC and validated by RT-qPCR. It was proposed as a diagnostic marker for GC and PDGA, and its m6A modification level correlated with expression.
Confidence score:

0.6709
Other information
Title:

Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.

Journal: Epigenomics
Published: 2020
PubMed ID: 32657141
Study type:

combined biological and clinical study
Data availability: -
Code availability: -