| Expression pattern: |
UP |
| Associated gene: |
RAB10, HK2, GLUT1 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
circ-PTN promotes glioma cell proliferation, invasion, glycolysis and xenograft tumor growth; knockdown of circ-PTN suppresses these malignant phenotypes. |
| Molecular mechanism: |
circ-PTN functions as a ceRNA for miR-432-5p to regulate RAB10 expression, thereby modulating glioma proliferation, invasion and glycolysis. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ-PTN might serve as an important target for treatment of glioma. |
| Description: |
circ-PTN is up-regulated in glioma tissues and cell lines. Functional experiments indicate that circ-PTN promotes glioma cell proliferation, invasion, glycolysis and xenograft tumor growth. Mechanistically, circ-PTN acts as a ceRNA by binding miR-432-5p and regulating RAB10 expression, suggesting circ-PTN as a potential therapeutic target in glioma. |
| Confidence score: |
0.7177 |