circRNA basic information
circBase ID: -
Name: -
Synonym: hsa-circ_035997
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small-cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissues / cancer tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: miR-141-3p
Biological function: May help distinguish LUAD from LUSC (expression differs between subtypes); functional role in NSCLC not reported.
Molecular mechanism: Predicted ceRNA mechanism: binding to miR-141-3p.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

May be used to distinguish LUAD and LUSC.
Description:

hsa-circ_035997 is differentially expressed between LUAD and LUSC and was identified as a key circRNA node in the computational ceRNA analysis. It is predicted to bind miR-141-3p, suggesting a potential miRNA-sponge mechanism, but experimental validation was not performed.
Confidence score:

0.1768
Other information
Title:

A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs.

Journal: Genetics and molecular biology
Published: 2020
PubMed ID: 33196759
Study type:

combined biological and clinical study
Data availability: TCGA-LUAD; TCGA-LUSC
Code availability: -