| Expression pattern: |
UP |
| Associated gene: |
CHI3L1 |
| Associated microRNA: |
miR-1265 |
| Biological function: |
promotes osteosarcoma cell proliferation, migration and invasion; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circMMP9 sponges miR-1265 to modulate CHI3L1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Survival Analysis; Clinical Sample Validation; Cohort Study; Western Blot |
| Clinical significance: |
Overexpressed circMMP9 was correlated with advanced tumor stage and predicted poor prognosis. |
| Description: |
circMMP9 is up-regulated in osteosarcoma tissues/cell lines and its high level associates with advanced stage/metastasis and poorer survival. Functionally, circMMP9 promotes proliferation, migration and invasion and suppresses apoptosis by acting as a cytoplasmic sponge for miR-1265, thereby increasing CHI3L1 expression. |
| Confidence score: |
0.7617 |