circRNA basic information
circBase ID: hsa_circ_0009910
Name: hsa_circ_MFN2
Synonym: -
Host Gene: MFN2
Genomic location(hg19): chr1:12049221-12052747:+
Genomic location(hg38): chr1:11989164-11992690:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

ovarian cancer tissues; corresponding normal ovarian tissues; tumor tissues; para-carcinoma tissues
Cell lines:

SKOV3; HEK-293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: cyclin D1, CDK4, CDK6, MMP-2, MMP-9, IkappaBalpha, p65, Notch1, Hes1, Hes5
Associated microRNA: miR-145
Biological function: hsa_circ_0009910 promotes ovarian cancer cell proliferation, viability, migration and invasion, and its silencing represses these phenotypes.
Molecular mechanism: hsa_circ_0009910 functions as a miRNA sponge that directly targets and suppresses miR-145, thereby promoting ovarian cancer cell phenotypes and activating NF-kappaB and Notch pathways.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); NF-kappaB (promotes); Notch (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Survival Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0009910 is accumulated in ovarian cancer tissues and its upregulation represents unfavorable prognosis.
Description:

hsa_circ_0009910 is up-regulated in ovarian cancer tissues and high expression is associated with poor prognosis. Functionally, it promotes ovarian cancer cell proliferation, viability, migration and invasion. Mechanistically, hsa_circ_0009910 directly targets and suppresses miR-145, contributing to activation of NF-kappaB and Notch signaling.
Confidence score:

0.7618
Other information
Title:

Hsa_circ_0009910: oncogenic circular RNA targets microRNA-145 in ovarian cancer cells.

Journal: Cell cycle (Georgetown, Tex.)
Published: 2020
PubMed ID: 32588730
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -