| Expression pattern: |
UP |
| Associated gene: |
cyclin D1, p53, MMP-9, vimentin, JAK1, STAT3, AMPK |
| Associated microRNA: |
miR-124 |
| Biological function: |
circDOCK1 promotes thyroid cancer cell viability, proliferation, migration and invasion; increases cyclin D1, MMP-9 and vimentin; decreases p53; and activates JAK/STAT/AMPK signaling through downregulation of miR-124. |
| Molecular mechanism: |
circDOCK1 downregulates miR-124, thereby inducing phosphorylation of JAK1, STAT3 and AMPK and promoting thyroid cancer cell growth, migration and invasion. |
| Biological pathway or process: |
JAK/STAT (promotes); AMPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Western Blot |
| Clinical significance: |
circDOCK1 was enriched in thyroid carcinoma tissues from 25 patients compared with para-carcinoma tissues. |
| Description: |
circDOCK1 is up-regulated in thyroid carcinoma tissues and acts as a pro-tumor circRNA in human thyroid cancer cell lines. The study suggests that circDOCK1 downregulates miR-124, activates JAK/STAT/AMPK signaling, and thereby promotes cell viability, proliferation, migration and invasion. |
| Confidence score: |
0.5214 |