| Expression pattern: |
DN |
| Associated gene: |
FOXO1 / forkhead box O1 |
| Associated microRNA: |
miR-411-5p |
| Biological function: |
Circ_0000353 functions as a tumor suppressor in NSCLC; its over-expression restrains NSCLC cell proliferation, migration, invasion and metastasis, while knockdown has opposite effects. |
| Molecular mechanism: |
Circ_0000353 acts as a ceRNA/molecular sponge for miR-411-5p, suppresses miR-411-5p expression, and increases FOXO1 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; BrdU; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Decreased circ_0000353 expression was significantly associated with increased clinical stage, larger tumor volume and metastasis, and low expression may serve as an indicator to help evaluate NSCLC prognosis. |
| Description: |
Circ_0000353 is down-regulated in NSCLC tissues and cell lines, and its reduced expression is associated with advanced clinical features. Functionally, circ_0000353 suppresses NSCLC cell proliferation, migration, invasion and metastasis. Mechanistically, it acts as a ceRNA by adsorbing miR-411-5p, thereby increasing FOXO1 expression. |
| Confidence score: |
0.6536 |