circRNA basic information
circBase ID: hsa_circ_0058792
Name: hsa_circ_AGAP1
Synonym: circAGAP1
Host Gene: hsa-miR-216a-3p
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human RCC cell lines (786-O, ACHN, Caki-1, A498), normal kidney cell line (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MKNK2
Associated microRNA: hsa-miR-216a-3p
Biological function: Depleting circAGAP1 effectively hampered the proliferative, invasive, and migratory capacities, EMT, and immune escape of ccRCC cells. Correspondingly, silencing circAGAP1 delayed tumor growth, distant metastasis, and immune escape in vivo
Molecular mechanism: circAGAP1/hsa-miR-216a-3p/MKNK2 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Collectively, our findings demonstrate that circAGAP1 exerts a tumor suppressor function through miR-216a-3p/MKNK2 during the immune escape and distant metastasis in ccRCC, and suggest that circAGAP1 may be a novel prognostic marker and therapeutic target for ccRCC.
Other information
Title:

Circular RNA AGAP1 Stimulates Immune Escape and Distant Metastasis in Renal Cell Carcinoma.

Journal: Mol Biotechnol
Published: 2023/5/19
PubMed ID: 37202649