circRNA basic information
circBase ID: hsa_circ_0005758
Name: hsa_circ_KIAA0907
Synonym: -
Host Gene: KIAA0907
Genomic location(hg19): chr1:155891165-155893478:-
Genomic location(hg38): chr1:155921374-155923687:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent non-tumorous tissues; healthy gastric mucosa; gastritis mucosa; gastric intestinal metaplasia tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May play an important role in gastric carcinogenesis; potential diagnostic indicator for GC (including early GC).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Down-regulated in GC tissues; relevant to tissue CEA level and perineural invasion; diagnostic value by ROC (AUC 0.721).
Description:

hsa_circ_0005758 (host gene KIAA0907) is significantly down-regulated in gastric cancer tissues and correlates with tissue CEA level and perineural invasion. It has diagnostic potential for distinguishing GC tissues from controls by ROC analysis (AUC 0.721).
Confidence score:

0.559
Other information
Title:

Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues.

Journal: Journal of clinical laboratory analysis
Published: 2019
PubMed ID: 31328820
Study type:

clinical study
Data availability: -
Code availability: -