circRNA basic information
circBase ID: hsa_circ_0072088
Name: hsa_circ_ZFR
Synonym: -
Host Gene: ZFR
Genomic location(hg19): chr5:32379220-32388780:-
Genomic location(hg38): chr5:32379114-32388674:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent normal tissue
Cell lines:

A549; H1299; 16HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ONECUT2, PRDM16, RPS27A, NEDD8, THBS1, COL1A1, ADAM9, PEG10, SIRT1, TGFB1, JUN, CREB1, TRIM33, WNT5A, CITED2, CACNG1, SRF, DDIT3, TRAF6, MAP4K2, FGFR2, FGF2, CACNG8, SOD2, IGF1R, PIK3CA, PRKAA2, ATG12
Associated microRNA: miR-578, miR-944
Biological function: unknown
Molecular mechanism: ceRNA (miRNA sponge) network prediction
Biological pathway or process:

ceRNA regulation (other); TGF-beta/SMAD (other); MAPK (other); PI3K/AKT (other)
Detected method:
Q
S
M
Validation methods:

Microarray; RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0072088 is up-regulated in lung adenocarcinoma and was validated in matched tissues and LUAD cell lines. The study predicts it may act as a ceRNA by sponging miRNAs (notably miR-578/miR-944) to influence downstream cancer-related genes and pathways including TGF-beta-related responses and MAPK/PI3K-AKT signaling.
Confidence score:

0.5739
Other information
Title:

Identification of circRNA-miRNA-mRNA Networks for Exploring the Fundamental Mechanism in Lung Adenocarcinoma.

Journal: OncoTargets and therapy
Published: 2020
PubMed ID: 32308427
Study type:

combined biological and clinical study
Data availability: GSE101586; GSE101684; GSE104854
Code availability: -