circRNA basic information
circBase ID: -
Name: ebv_circ_RPMS1
Synonym: circRPMS1_E4_E3a
Host Gene: RPMS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: stomach cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Virus
Species details: Human gammaherpesvirus 4 / Epstein-Barr virus
Tissue specimen:

stomach cancer biopsies; normal adjacent tissue; tumor tissue
Cell lines:

SNU719; YCCEL1; Akata; Mutu I; Sav I; Mutu III; IB4; JY
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: unknown
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; divergent primers PCR; Back-Splice Junction PCR; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation
Clinical significance:

Detected in EBV positive clinical stomach cancer specimens (2/2 biopsies tested).
Description:

circRPMS1_E4_E3a is an EBV RPMS1-locus circRNA expressed across latency types and detectable in EBV-positive stomach cancer biopsies. It is predominantly nuclear with possible low cytoplasmic localization; the study suggests it could affect miRNA processing due to its splice-acceptor context, but its function in tumors remains unproven.
Confidence score:

0.6235
Other information
Title:

The Epstein Barr virus circRNAome.

Journal: PLoS pathogens
Published: 2018
PubMed ID: 30080890
Study type:

combined biological and clinical study
Data availability: GSE52490
Code availability: -