| Expression pattern: |
UP |
| Associated gene: |
KIF20A |
| Associated microRNA: |
hsa-miR-124-3p |
| Biological function: |
promotes glioma cell proliferation, migration and invasion; inhibits apoptosis; promotes in vivo tumor progression |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circ-Serpine2 sponges miR-124-3p to upregulate KIF20A |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Transfection; Western Blot; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Nuclear-Cytoplasmic Fractionation; In Vivo Animal Model; H&E Staining; Microarray |
| Clinical significance: |
providing novel predictive/prognostic biomarkers and drug targets against glioma |
| Description: |
circ-Serpine2 is upregulated in GSC23-derived exosomal context and acts predominantly in the cytoplasm as a ceRNA. It sponges miR-124-3p to increase KIF20A, thereby promoting glioma cell proliferation/migration/invasion and inhibiting apoptosis, and it enhances tumor growth in a xenograft model. |
| Confidence score: |
0.5318 |