| Expression pattern: |
UP |
| Associated gene: |
Myc |
| Associated microRNA: |
miR-182 |
| Biological function: |
promotes ESCC cell viability, colony formation, invasion, and tumor growth in vivo |
| Molecular mechanism: |
acts as a miRNA sponge for miR-182 to increase Myc expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis; In Vivo Animal Model |
| Clinical significance: |
high circ-LRP6 correlated with malignant clinicopathological characteristics and poor prognosis |
| Description: |
circ-LRP6 is up-regulated in ESCC tissues and promotes ESCC proliferation/invasion and xenograft tumor growth. Mechanistically, it localizes mainly in the cytoplasm and functions as a ceRNA by sponging miR-182, thereby relieving repression of Myc and increasing Myc expression; clinically, higher circ-LRP6 associates with advanced features and poorer survival. |
| Confidence score: |
0.8555 |