| Expression pattern: |
UP |
| Associated gene: |
eIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Promotes viral RNA abundance/replication (pro-viral factor) in HCV- and DENV-infected liver cells. |
| Molecular mechanism: |
Acts at a post-translational step to enhance viral RNA amplification; binds eIF4A3 and may modulate the cellular NMD pathway, but circPSD3 and eIF4A3 affect HCV RNA abundances by distinct mechanisms. |
| Biological pathway or process: |
viral replication (promotes); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Transfection; FISH / smFISH; RNase R Treatment; In Vivo Animal Model; Luciferase Reporter Assay; MTT; Northern Blot; droplet digital PCR (ddPCR); Western Blot |
| Clinical significance: |
- |
| Description: |
circPSD3 is up-regulated in HCV-infected liver cells and functions as a pro-viral factor that increases HCV RNA abundance; it also promotes DENV infectivity. Mechanistically, it binds eIF4A3 and can modulate NMD substrates, but its pro-viral effect occurs mainly at a post-translational step and is independent of eIF4A3’s antiviral NMD-related effects. |
| Confidence score: |
0.6913 |