| Expression pattern: |
UP |
| Associated gene: |
Bcl2, Vimentin, N-cadherin, E-cadherin, cleaved caspase-3 |
| Associated microRNA: |
miR-27b-3p |
| Biological function: |
Promotes gastric cancer cell growth, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge by binding miR-27b-3p, thereby regulating apoptosis- and EMT-related proteins. |
| Biological pathway or process: |
apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
High expression of circR-RNF111 was significantly and positively associated with tumor size, stage, lymphatic metastasis, distant metastasis and invasion. |
| Description: |
hsa_circ_0001982 (circR-RNF111) is up-regulated in gastric cancer tissues and cell lines and correlates with aggressive clinicopathological features. Functionally, circR-RNF111 promotes proliferation, migration and invasion while inhibiting apoptosis in GC cells, at least partly by sponging miR-27b-3p and modulating apoptosis- and EMT-related protein expression. |
| Confidence score: |
0.6542 |