circRNA basic information
circBase ID: hsa_circ_0011946
Name: hsa_circ_SCMH1
Synonym: -
Host Gene: SCMH1
Genomic location(hg19): chr1:41578954-41618413:-
Genomic location(hg38): chr1:41113282-41152741:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; corresponding adjacent non-cancerous tissues
Cell lines:

MCF-7; HS-578T; T47D; BT549; MDA-MB-231; SKBR-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RFC3
Associated microRNA: miR-26a, miR-26b
Biological function: promotes migration and invasion
Molecular mechanism: Bioinformatics-predicted miRNA sponge (miR-26a/b) regulating RFC3; knockdown of hsa_circ_0011946 suppresses RFC3 mRNA and protein expression.
Biological pathway or process:

migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0011946 is up-regulated in breast cancer tissues and shows higher expression in MCF-7 cells. siRNA-mediated knockdown of hsa_circ_0011946 suppresses MCF-7 cell migration and invasion and decreases RFC3 mRNA/protein; a predicted ceRNA mechanism involves sponging miR-26a/b to regulate RFC3.
Confidence score:

0.7477
Other information
Title:

Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.

Journal: Cancer management and research
Published: 2018
PubMed ID: 29593432
Study type:

combined biological and clinical study
Data availability: -
Code availability: -