circRNA basic information
circBase ID: -
Name: hsa_circ_TGFBR2
Synonym: -
Host Gene: TGFBR2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissues; paired normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: TGFBR2
Associated microRNA: -
Biological function: Predicted to inhibit expression of its host gene TGFBR2, possibly through competition with linear RNA during splicing.
Molecular mechanism: Predicted host gene regulation through competition with linear RNA during splicing.
Biological pathway or process:

other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circTGFBR2 was identified as a dysregulated circRNA in cervical cancer with an inverse expression relationship to its host gene TGFBR2. The study predicted that circTGFBR2 may inhibit TGFBR2 expression, possibly by competing with linear RNA during splicing.
Confidence score:

0.1768
Other information
Title:

Identification and characterization of tumorigenic circular RNAs in cervical cancer.

Journal: Cellular signalling
Published: 2020
PubMed ID: 32423867
Study type:

bioinformatics study
Data availability: SRP125806; https://doi.org/10.1016/j.cellsig.2020.109669
Code availability: -