circRNA basic information
circBase ID: hsa_circ_0008928
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:200213423-200298237:-
Genomic location(hg38): chr2:199348700-199433514:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

xenograft tumor tissues
Cell lines:

SMMC-7721; Hep3B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May be involved in regulating the synergistic anti-tumor effect of berberine and regorafenib in HCC cells.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Transfection; EdU Staining; TUNEL; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

In HCC cells treated with berberine plus regorafenib, hsa_circ_0008928 is up-regulated and highlighted as a candidate circRNA potentially linked to the synergistic anti-tumor activity of the drug combination. The study did not experimentally define its direct targets or a specific regulatory axis.
Confidence score:

0.5089
Other information
Title:

Berberine Sensitizes Human Hepatoma Cells to Regorafenib via Modulating Expression of Circular RNAs.

Journal: Frontiers in pharmacology
Published: 2021
PubMed ID: 34220494
Study type:

biological research
Data availability: NCBI BioProject PRJNA701123
Code availability: -