| Expression pattern: |
DN |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-382-5p |
| Biological function: |
Tumor suppressor role in CRC; inhibits CRC cell proliferation and migration. |
| Molecular mechanism: |
circ_0008285 sponges miR-382-5p to elevate PTEN expression and suppresses the PI3K/AKT pathway. |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; RNA-seq; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Decreased circ_0008285 expression was correlated with larger tumor size, more lymphatic metastasis, and higher TNM stage; circ_0008285 may be a potential therapeutic target for CRC treatment. |
| Description: |
hsa_circ_0008285/circ_0008285 is downregulated in CRC tissues and cell lines and acts as a tumor-suppressive circRNA. It inhibits CRC cell proliferation and migration by sponging miR-382-5p, upregulating PTEN, and suppressing PI3K/AKT signaling; lower expression correlates with larger tumor size, lymphatic metastasis, and advanced TNM stage. |
| Confidence score: |
0.802 |