circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005005
MONDO name: clear cell renal carcinoma
Disease details: clear cell renal carcinoma
Disease DO ID:
 4467
Disease MeSH ID:
 -
Disease NCIt ID:
 C4033
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

CCRCC tissues; matched adjacent normal renal tissues; normal kidney tissues
Cell lines:

CAKi-1; Caki-1; Caki1; 786O; ACHN; A498; HK-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-637
Biological function: Overexpression of circHIPK3 suppresses CCRCC cell invasion, migration, and proliferation in vitro, and inhibits CCRCC cell growth in vivo; circHIPK3 may act as a tumor suppressor.
Molecular mechanism: circHIPK3 may function through a circRNA-miRNA axis by targeting miR-637 in CCRCC cells.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay
Clinical significance:

circHIPK3 may represent a potential therapeutic target in CCRCC patients.
Description:

circHIPK3 is downregulated in CCRCC tissues and cell lines. Its overexpression suppresses CCRCC migration, invasion, and proliferation in vitro and inhibits xenograft tumor growth in vivo, suggesting a tumor-suppressive role. Mechanistically, circHIPK3 may target miR-637 in CCRCC cells.
Confidence score:

0.7591
Other information
Title:

Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma.

Journal: Journal of molecular histology
Published: 2020
PubMed ID: 32409849
Study type:

combined biological and clinical study
Data availability: Supplementary Table S2; Supplemental Table S3
Code availability: -