| Expression pattern: |
UP |
| Associated gene: |
GRIN2B, PTPRF, RAD23B |
| Associated microRNA: |
hsa-miR-1253, hsa-miR-153-5p, hsa-miR-660-5p, hsa-miR-766-5p, hsa-miR-877-3p |
| Biological function: |
biomarker for diagnosis of immune-mediated demyelinating diseases; associated with CSF IgG levels |
| Molecular mechanism: |
Predicted ceRNA mechanism (circRNA/miRNA/mRNA network); correlated with CSF IgG levels by canonical correlation analysis |
| Biological pathway or process: |
ceRNA regulation (other); p53 signaling (other); autophagy (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
Diagnostic accuracy was 100% when hsa_circ_0012077 was employed alone for diagnosing immune-mediated demyelinating disease (AUC = 1.00). |
| Description: |
Exosomal hsa_circ_0012077 is up-regulated in CSF from patients with immune-mediated demyelinating diseases and has perfect diagnostic performance (AUC=1.00) in this cohort. Its expression level is correlated with CSF IgG levels, and it is predicted to act in a ceRNA network involving miRNAs and target genes such as GRIN2B. |
| Confidence score: |
0.5534 |