| Expression pattern: |
UP |
| Associated gene: |
CREBRF, Ago2 |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion, EMT-associated malignant behaviors and xenograft tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0081723 functions as a ceRNA/molecular sponge for miR-545-3p, thereby regulating CREBRF expression and promoting cervical cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0081723 might be a biomarker and a possible circRNA-targeted therapeutic target for cervical cancer. |
| Description: |
circ_0081723 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes CC cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through sponging miR-545-3p to regulate CREBRF. The study suggests circ_0081723 may serve as a biomarker and therapeutic target for cervical cancer. |
| Confidence score: |
0.8175 |