| Expression pattern: |
UP |
| Associated gene: |
MDM4, Bcl-2, Bax, p53 |
| Associated microRNA: |
microRNA-126-3p / miR-126 |
| Biological function: |
circ9119 acts as an oncogene in cervical cancer, promotes CC cell proliferation and xenograft tumor growth, and suppresses apoptosis; circ9119 silencing reduces proliferation, induces apoptosis, and suppresses tumor growth. |
| Molecular mechanism: |
circ9119 functions as a ceRNA/miR-126 sponge to increase MDM4 expression, forming a circ9119/miR-126/MDM4 regulatory axis that influences p53 expression and apoptosis-related proteins. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other); p53 signaling (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ9119 may be a therapeutic target for cervical cancer. |
| Description: |
circ9119 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation and tumor growth while inhibiting apoptosis by sponging miR-126 and increasing MDM4 expression, with the circ9119/miR-126/MDM4 axis implicated in CC occurrence and progression. |
| Confidence score: |
0.6536 |