circRNA basic information
circBase ID: hsa_circ_0050102
Name: hsa_circ_PGPEP1
Synonym: Circ_0050102
Host Gene: PGPEP1
Genomic location(hg19): chr19:18459757-18466821:+
Genomic location(hg38): chr19:18348947-18356011:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PC tissue; normal tissue
Cell lines:

SW1990; Capan-1; HPDE; HUVEC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PPME1
Associated microRNA: miR-218-5p
Biological function: promotes proliferation, colony formation, migration, invasion, angiogenesis and inhibits apoptosis in pancreatic cancer cells; promotes tumor growth in vivo
Molecular mechanism: hsa_circ_0050102 sponges miR-218-5p to increase PPME1 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation
Clinical significance:

high hsa_circ_0050102 was frequently observed in PC patients with the advanced clinical stage and lymph node metastasis
Description:

hsa_circ_0050102 is up-regulated in pancreatic cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes pancreatic cancer cell proliferation, migration/invasion and angiogenesis and inhibits apoptosis by sponging miR-218-5p to increase PPME1 expression, and its knockdown suppresses xenograft tumor growth.
Confidence score:

0.8039
Other information
Title:

Hsa_circ_0050102 regulates the pancreatic cancer development via miR-218-5p/PPME1 axis.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35060203
Study type:

combined biological and clinical study
Data availability: The datasets used and analysed during this study are available from the corresponding author on reasonable request.
Code availability: -