circRNA basic information
circBase ID: hsa_circ_0084003
Name: hsa_circ_FGFR1
Synonym: circFGFR1
Host Gene: FGFR1
Genomic location(hg19): chr8:38271435-38285611:-
Genomic location(hg38): chr8:38413917-38428093:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

xenograft tumors
Cell lines:

NHA; U251MG; U87MG; U118MG; T98G; SNB19; DBTRG-05; GBM 8401
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCR4 mRNA, CXCR4, AGO2
Associated microRNA: hsa-miR-224-5p
Biological function: Promotes glioma malignant behaviors including invasion, migration, proliferation and tumor growth.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for hsa-miR-224-5p to upregulate CXCR4 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; circRIP; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

circFGFR1 is upregulated in glioma/GBM cell models and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges hsa-miR-224-5p to relieve repression of CXCR4, thereby increasing CXCR4 expression and driving oncogenic phenotypes.
Confidence score:

0.7703
Other information
Title:

Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p.

Journal: Journal of immunology research
Published: 2022
PubMed ID: 35059468
Study type:

biological research
Data availability: available from the corresponding author upon request
Code availability: -