| Expression pattern: |
UP |
| Associated gene: |
FGFR1 |
| Associated microRNA: |
miR-198 |
| Biological function: |
promotes proliferation, migration and invasion/metastasis in thyroid cancer cells |
| Molecular mechanism: |
Acts as a miR-198 sponge (ceRNA) to upregulate FGFR1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
may be a potential marker for TC diagnosis or progression |
| Description: |
circITGA7 is upregulated in thyroid cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes thyroid cancer cell proliferation and metastatic behaviors by acting as a ceRNA that sponges miR-198, thereby relieving miR-198-mediated repression of FGFR1 and increasing FGFR1 expression. |
| Confidence score: |
0.6777 |