| Expression pattern: |
DN |
| Associated gene: |
PTEN, Bax |
| Associated microRNA: |
miR-214 |
| Biological function: |
circ-ITCH functions as a tumor suppressor in NPC; its upregulation inhibits NPC cell proliferation, migration, invasion and tumorigenesis in vivo. |
| Molecular mechanism: |
circ-ITCH sponges miR-214 to upregulate PTEN expression, thereby inhibiting NPC proliferation, migration, invasion and tumorigenesis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ-ITCH expression was inversely correlated with TNM stage, clinical stage and lymphatic metastasis in patients with NPC, and circ-ITCH may serve as a therapeutic target for NPC treatment. |
| Description: |
circ-ITCH is downregulated in nasopharyngeal carcinoma tissues and cell lines. Functionally, circ-ITCH acts as a tumor suppressor by inhibiting NPC cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it sponges miR-214 to relieve repression of PTEN, and lower circ-ITCH expression is associated with more advanced TNM stage, clinical stage and lymphatic metastasis. |
| Confidence score: |
0.713 |