| Expression pattern: |
DN |
| Associated gene: |
UPF1 |
| Associated microRNA: |
- |
| Biological function: |
Circular RNA_LARP4 acts as a tumor suppressor in gastric cancer by inhibiting GC cell proliferation, colony formation, cell cycle progression, migration, invasion, and metastasis. |
| Molecular mechanism: |
Circular RNA_LARP4 inhibits gastric cancer cell proliferation and metastasis through upregulating UPF1. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circular RNA_LARP4 might provide a new tumor suppressor and a clinical tool for predicting treatment response and assessing disease state and clinical outcome of GC. |
| Description: |
Circular RNA_LARP4 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses GC cell proliferation, colony formation, cell cycle progression, migration and invasion, likely through upregulation of UPF1. The study suggests Circular RNA_LARP4 may function as a tumor suppressor and potential clinical indicator in GC. |
| Confidence score: |
0.5758 |