| Expression pattern: |
UP |
| Associated gene: |
synoviolin 1 (SYVN1) |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
promotes proliferation and cell viability, migration and invasion; inhibits apoptosis in hepatocellular carcinoma cells |
| Molecular mechanism: |
circ-SOX5 acts as a miRNA sponge for miR-502-5p, thereby upregulating SYVN1 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ-SOX5 may be a potential biomarker of HCC |
| Description: |
circ-SOX5 is up-regulated in HCC tissues/serum and HCC cell lines. It promotes HCC cell proliferation/viability and migration/invasion while inhibiting apoptosis via a ceRNA mechanism by sponging miR-502-5p and upregulating SYVN1. |
| Confidence score: |
0.8122 |