| Expression pattern: |
UP |
| Associated gene: |
HOXB13, NF-kappaB/p65, p65 |
| Associated microRNA: |
miR-7 |
| Biological function: |
promotes proliferation, migration, invasion, tumor growth and lung metastasis in ESCC |
| Molecular mechanism: |
ciRS-7 acts as a miR-7 sponge (ceRNA) to relieve repression of HOXB13 and activate HOXB13-mediated NF-kappaB/p65 signaling (p65 phosphorylation). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); NF-kappaB (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
Upregulation/high expression of ciRS-7 predicts poor outcome and is associated with poor patient survival in ESCC; may act as a prognostic marker. |
| Description: |
ciRS-7 (Cdr1as) is up-regulated in ESCC tissues and cell lines and its high expression is associated with worse OS/DFS. Functionally, ciRS-7 promotes ESCC malignant progression by sponging miR-7, thereby de-repressing HOXB13 and activating the HOXB13-mediated NF-kappaB/p65 (p65 phosphorylation) pathway, enhancing proliferation and metastasis. |
| Confidence score: |
0.7344 |