| Expression pattern: |
DN |
| Associated gene: |
UBE2A |
| Associated microRNA: |
miRNA-7 |
| Biological function: |
Acts as an endogenous miRNA-7 sponge; its deficiency is associated with increased ambient miRNA-7 and reduced expression of miRNA-7-sensitive targets (e.g., UBE2A), potentially impairing ubiquitin-proteasome-mediated amyloid clearance in sporadic AD brain. |
| Molecular mechanism: |
ciRS-7 functions as a competing endogenous RNA (ceRNA) sponge for miRNA-7, modulating miRNA-7 availability and thereby affecting miRNA-7-targeted mRNAs such as UBE2A. |
| Biological pathway or process: |
ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
B
|
| Validation methods: |
RNase R Treatment; Northern Blot; Clinical Sample Validation |
| Clinical significance: |
ciRS-7 is significantly reduced in sporadic AD neocortex (Brodmann A22) and hippocampal CA1, as part of a misregulated ciRS-7-miRNA-7-UBE2A circuit. |
| Description: |
In sporadic Alzheimer’s disease brain (neocortex A22 and hippocampal CA1), ciRS-7 is markedly down-regulated. Loss of this miRNA-7 sponge is linked to increased ambient miRNA-7 and reduced expression of miRNA-7-sensitive targets such as UBE2A, implicating a disrupted circRNA/miRNA/mRNA regulatory circuit relevant to AD pathology. |
| Confidence score: |
0.429 |