circRNA basic information
circBase ID: hsa_circ_0008673
Name: hsa_circ_BRCA1
Synonym: -
Host Gene: BRCA1
Genomic location(hg19): chr17:41247862-41276132:-
Genomic location(hg38): chr17:43095845-43124115:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

MCF-10A; MCF-10AT; MCF-10CA1A; MCF-10CA1H; MDA-MB-231; MDA-MB-468; MCF-7; T47D
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes tumor cell proliferation and metastasis (migration/invasion); knockdown induces G1 phase cell cycle arrest
Molecular mechanism: -
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Transfection; MTT; Cell Cycle Assay; Transwell Assay
Clinical significance:

plasma cell-free hsa_circ_0008673 distinguishes breast cancer patients from healthy controls (AUC 0.833) and high expression predicts worse OS and DSS
Description:

hsa_circ_0008673 is up-regulated in breast cancer patient plasma and breast cancer cell lines. High plasma levels have diagnostic value and are associated with worse OS/DSS. Functionally, hsa_circ_0008673 promotes proliferation and metastatic traits, as its knockdown induces G1 arrest and suppresses migration/invasion in MDA-MB-231 and MCF-7 cells.
Confidence score:

0.7408
Other information
Title:

Identification of plasma hsa_circ_0008673 expression as a potential biomarker and tumor regulator of breast cancer.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 32808350
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -