| Expression pattern: |
UP |
| Associated gene: |
ACER3 |
| Associated microRNA: |
miR-655-3p |
| Biological function: |
promotes HCC tumorigenesis by promoting proliferation, migration, invasion, angiogenesis and EMT, and inhibiting apoptosis; supports tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponge: circ_0001955 sponges miR-655-3p to up-regulate ACER3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); EMT (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis; Microarray |
| Clinical significance: |
circ_0001955 expression was correlated with TNM stage and tumor size; higher in stage III than stage I-II |
| Description: |
circ_0001955 is up-regulated in hepatocellular carcinoma and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion, angiogenesis and EMT while inhibiting apoptosis, largely by sponging miR-655-3p to increase ACER3 expression; its knockdown suppresses tumor growth in xenografts. |
| Confidence score: |
0.8256 |