circRNA basic information
circBase ID: -
Name: ebv_circ_BHLF1
Synonym: -
Host Gene: BHLF1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: stomach cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Virus
Species details: Human gammaherpesvirus 4 / Epstein-Barr virus
Tissue specimen:

-
Cell lines:

Akata; Mutu I; Jijoye; JY; SNU719; YCCEL1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: OriLyt DNA
Associated microRNA: -
Biological function: may facilitate lytic viral DNA replication (speculative)
Molecular mechanism: possible association with replication complex / R-loop at oriLyt (speculative)
Biological pathway or process:

viral replication (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; divergent primers PCR; Back-Splice Junction PCR; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization)
Clinical significance:

-
Description:

circBHLF1 (and the closely related circBHLF1alt isoform) is a highly abundant EBV lytic circRNA during reactivation, RNase R-resistant, and predominantly nuclear by RT-qPCR and BaseScope. The paper discusses a plausible role in lytic DNA replication due to proximity to oriLyt, but this remains speculative without direct functional assays.
Confidence score:

0.5337
Other information
Title:

The Epstein Barr virus circRNAome.

Journal: PLoS pathogens
Published: 2018
PubMed ID: 30080890
Study type:

biological research
Data availability: GSE52490
Code availability: -