| Expression pattern: |
UP |
| Associated gene: |
TWIST1 |
| Associated microRNA: |
miR-409-3p |
| Biological function: |
Promotes proliferation, invasion, migration and EMT and inhibits apoptosis in breast cancer cells; circCNOT2 knockdown shows the opposite effects. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (miRNA sponge) for miR-409-3p to derepress/mediate TWIST1 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
Elevated circCNOT2 is associated with poor prognosis of BC. |
| Description: |
circCNOT2 is up-regulated in breast cancer tissues/cells and correlates with worse survival. Functionally, circCNOT2 promotes proliferation, invasion, migration and EMT while inhibiting apoptosis in BC cells. Mechanistically, circCNOT2 acts as a ceRNA sponging miR-409-3p to increase TWIST1 expression (circCNOT2/miR-409-3p/TWIST1 axis). |
| Confidence score: |
0.7537 |