| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-873 |
| Biological function: |
hsa_circ_0102231 promotes liver cancer progression, cell proliferation, cell migration, and tumor growth; knockdown of hsa_circ_0102231 suppresses these malignant phenotypes. |
| Molecular mechanism: |
hsa_circ_0102231 acts as a miR-873 sponge and promotes SOX4 expression, thereby driving liver cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
hsa_circ_0102231 may have potential in diagnosis and treatment of liver cancer and is described as associated with prognosis of liver cancer. |
| Description: |
hsa_circ_0102231 is up-regulated in liver cancer cell lines and promotes liver cancer progression. Its knockdown inhibits proliferation, migration, and xenograft tumor growth by increasing miR-873 and reducing SOX4 expression through the miR-873/SOX4 regulatory axis. |
| Confidence score: |
0.627 |