circRNA basic information
circBase ID: hsa_circ_0056537
Name: hsa_circ_CCNT2
Synonym: circCCNT2
Host Gene: CCNT2
Genomic location(hg19): chr2:135694410-135700244:+
Genomic location(hg38): chr2:134936841-134942674:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004985
MONDO name: bipolar disorder
Disease details: bipolar disorder
Disease DO ID:
 3312
Disease MeSH ID:
 D001714
Disease NCIt ID:
 C34423
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

anterior cingulate cortex (ACC) post-mortem human brain tissue; peripheral blood (B-lymphoblastoid cell lines source)
Cell lines:

B-lymphoblastoid cells / B-LCL
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RBPs
Associated microRNA: miR-877-5p
Biological function: Associated with bipolar disorder in anterior cingulate cortex and B-LCLs; reduced by lithium treatment in vitro.
Molecular mechanism: Predicted interactions with miR-877-5p and multiple RNA-binding proteins; potential m6A modification suggested by GRACH motifs; no ORFs/IRE elements detected.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circCCNT2 is associated with bipolar disorder and lithium treatment; upregulated in BD and reduced by lithium in vitro.
Description:

circCCNT2 (hsa_circ_0056537), derived from CCNT2, is upregulated in bipolar disorder in post-mortem anterior cingulate cortex and also elevated in BD-derived B-lymphoblastoid cells. Lithium treatment reduces circCCNT2 expression in vitro, and bioinformatic predictions suggest potential interactions with miR-877-5p and multiple RBPs, though functional mechanisms were not experimentally established.
Confidence score:

0.6193
Other information
Title:

Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder.

Journal: Translational psychiatry
Published: 2021
PubMed ID: 34893581
Study type:

combined biological and clinical study
Data availability: Supplementary Table 2; Supplementary Table 3; Supplementary Table 4; 10.1038/s41398-021-01746-4
Code availability: -