circRNA basic information
circBase ID: hsa_circ_0005729
Name: hsa_circ_RNF138
Synonym: -
Host Gene: RNF138
Genomic location(hg19): chr18:29691716-29693823:+
Genomic location(hg38): chr18:32111753-32113860:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006890
MONDO name: parathyroid gland adenoma
Disease details: parathyroid adenoma
Disease DO ID:
 7608
Disease MeSH ID:
 -
Disease NCIt ID:
 C156757
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

parathyroid tumor tissue; cervical tumor recurrence tissue; lung metastases tissue; liver metastases tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RNF138 mRNA
Associated microRNA: -
Biological function: Improves diagnostic discrimination of parathyroid carcinoma versus parathyroid adenoma.
Molecular mechanism: Mechanism not studied; expression correlation with RNF138 mRNA assessed.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Higher hsa_circ_0005729 improves diagnostic accuracy for PC vs PA; AUC increased to 0.86 when combined with serum calcium, creatinine, and ALP.
Description:

hsa_circ_0005729 is up-regulated in parathyroid carcinoma tissue compared with parathyroid adenoma and can serve as a diagnostic biomarker. Combining hsa_circ_0005729 with serum calcium, creatinine, and ALP improves diagnostic performance (AUC up to 0.86). The study also assessed correlation with its host gene RNF138 mRNA, but did not elucidate a mechanism.
Confidence score:

0.6238
Other information
Title:

Hsa_circ_0005729 enhances accuracy in diagnosing parathyroid carcinoma.

Journal: Endocrine connections
Published: 2022
PubMed ID: 35029546
Study type:

combined biological and clinical study
Data availability: The datasets are available from the corresponding author upon reasonable request.
Code availability: -