| Expression pattern: |
UN |
| Associated gene: |
- |
| Associated microRNA: |
miR-150-5p, miR-194-3p, miR-515-5p |
| Biological function: |
promotes cell migration; little effect on cell proliferation |
| Molecular mechanism: |
may act as miRNA sponge (predicted binding sites for miR-150-5p, miR-194-3p and miR-515-5p) |
| Biological pathway or process: |
migration (promotes); proliferation (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RNase R Treatment; Sanger Sequencing; Transfection; Transwell Assay; Wound Healing Assay; MTT; Colony Formation Assay; Bioinformatics Analysis; RT-PCR |
| Clinical significance: |
- |
| Description: |
In NSCLC cell models, F-circSR2 (generated from the SLC34A2-ROS1 fusion gene) promotes cell migration while having little effect on proliferation. A potential miRNA-sponge mechanism was proposed based on bioinformatic prediction of miRNA binding sites, without direct functional validation. |
| Confidence score: |
0.6562 |