circRNA basic information
circBase ID: hsa_circ_0001955
Name: hsa_circ_CSNK1G1
Synonym: circ-CSNK1G1
Host Gene: CSNK1G1
Genomic location(hg19): chr15:64495280-64508912:-
Genomic location(hg38): chr15:64203081-64216713:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002108
MONDO name: thyroid cancer
Disease details: thyroid cancer
Disease DO ID:
 1781
Disease MeSH ID:
 -
Disease NCIt ID:
 C7510
Disease ICD11 ID:
 447433352
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; matched normal tissues
Cell lines:

IHH-4; HTH83; KTC-1; SW579; TPC-1; SNU-790; Nthy-ori 3-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MAPK1
Associated microRNA: miR-149-5p
Biological function: promotes proliferation, survival and invasion of thyroid cancer cells and promotes tumor growth in vivo
Molecular mechanism: ceRNA mechanism: circ-CSNK1G1 sponges miR-149-5p to relieve repression of MAPK1
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

circ-CSNK1G1 is up-regulated in thyroid cancer tissues/cell lines and promotes malignant phenotypes (proliferation, survival, invasion) and xenograft tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-149-5p, relieving miR-149-5p-mediated repression of MAPK1.
Confidence score:

0.7489
Other information
Title:

CircRNA casein kinase 1 gamma 1 (circ-CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR-149-5p sponge and relieving the suppression of miR-149-5p on mitogen-activated protein kinase 1 (MAPK1).

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35023214
Study type:

combined biological and clinical study
Data availability: GSE93522
Code availability: -