| Expression pattern: |
UP |
| Associated gene: |
CCND1, Ago2 |
| Associated microRNA: |
miR-1299 |
| Biological function: |
Circ-UBR1 promotes breast cancer cell proliferation, migration, invasion, cell cycle progression and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ-UBR1 acts as a ceRNA by sponging miR-1299 to positively regulate CCND1 expression, thereby facilitating breast cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ-UBR1 might be a potential biomarker for BC treatment. |
| Description: |
This study found that circ-UBR1 is up-regulated in breast cancer tissues and cell lines. Functionally, circ-UBR1 promotes proliferation, migration, invasion, cell-cycle progression and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ-UBR1 acts as a ceRNA for miR-1299 to increase CCND1 expression, forming a circ-UBR1/miR-1299/CCND1 regulatory axis. |
| Confidence score: |
0.8005 |