circRNA basic information
circBase ID: hsa_circ_0080414
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr7:69364271-69364484:+
Genomic location(hg38): chr7:69899285-69899498:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissues; paired normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ESR1, FOXL2, ZFPM2, FGF10, INHBB
Associated microRNA: -
Biological function: Predicted to function as a tumor suppressor in cervical cancer by maintaining normal cervix-related functions via downstream target genes.
Molecular mechanism: Predicted ceRNA regulation of downstream target genes involved in normal cervix function.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (inhibits)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

Downregulation of hsa_circ_0080414 might undermine normal cervix function via ESR1 and FOXL2, thereby causing unfavorable prognosis.
Description:

hsa_circ_0080414 was identified as a down-regulated tumorigenic circRNA in cervical cancer. It was predicted to act through a ceRNA network regulating downstream genes such as ESR1 and FOXL2, and its downregulation may impair normal cervix-related functions and contribute to unfavorable prognosis.
Confidence score:

0.348
Other information
Title:

Identification and characterization of tumorigenic circular RNAs in cervical cancer.

Journal: Cellular signalling
Published: 2020
PubMed ID: 32423867
Study type:

bioinformatics study
Data availability: SRP125806; TCGA cervical cancer cohort; https://doi.org/10.1016/j.cellsig.2020.109669
Code availability: -